16Nov

Rewiring Your Brain: Healing Begins with Safety in the Body

Rewiring Your Brain: Healing Begins with Safety in the Body

You are not broken; your body is protecting you.

What feels like illness, exhaustion, or endless symptoms is often your nervous system’s way of keeping you safe. If healing begins with safety in the body, then restoring the brain’s perception of safety is the next frontier. This means your symptoms are not a sign of failure, but signals inviting you to create new pathways for healing.

In Part 1, we explored how the vagus nerve and somatic practices help shift the body out of survival mode. That wired-but-exhausted feeling is one that so many people with chronic symptoms know well. You’re trying to breathe deeply and “be present,” but somehow end up Googling “Why my Lab Work Came Back Normal And I Feel Terrible?”

Now, in Part 2, we turn to the brain. Specifically, the limbic system, trauma loops, and how neuroplasticity gives us a real path to deep healing through brain retraining. It’s not all in your head; it’s in your brain, and that’s hopeful.

We’re going to unpack why those nagging thoughts, like “I’m never going to get better” or “maybe I missed something,” keep showing up repeatedly. And more importantly, how to gently rewire them with the right tools and strategies. Healing isn’t linear, but the brain’s ability to change means you’re never truly stuck.

Build healing pathways for your Brain 

Brain retraining is the intentional practice of shifting how the nervous system interprets internal and external cues, moving from a default state of threat detection to one of safety and connection.

It’s not about “thinking positively.” It’s about changing the wiring that governs how your brain and body respond to life, using specific tools to interrupt chronic stress patterns and build healing pathways. These responses, often rooted in past trauma or chronic illness, become automatic loops that keep the body stuck in survival mode.

When Trauma Makes the Past Feel Like the Present

Understanding the Loop That Keeps You in Survival Mode

When it comes to chronic stress and trauma, two key brain regions play a major role in how we perceive and respond to the world: the amygdala and the hippocampus.

The Amygdala
Often called the brain’s “fear center,” the amygdala is constantly scanning for danger. When overactive due to trauma, chronic illness, or prolonged sleep deprivation, it can trigger exaggerated fight-or-flight responses to otherwise neutral stimuli. In this state, even minor events, like a sudden car honk, an unexpected schedule change, or the ding of a single new email or text message, can feel life-threatening.

For those living with chronic illness, this hyper-alert state can feel all too familiar. Imagine waking up already exhausted and then opening your inbox to dozens of unread emails. To a calm nervous system, that’s just “a busy morning.” But for a brain wired by chronic stress, the amygdala may tag that inbox as danger. Suddenly, your heart races and your body braces, as if answering those emails is a matter of survival.

The Hippocampus
This region is responsible for memory consolidation and contextualizing present experiences. It helps determine whether something is a true threat or just a reminder of a past one. Chronic stress and inflammation can impair hippocampal function, making it harder to “update” the brain’s perception of safety. As a result, people may feel stuck in the past, reacting as if the trauma is still happening.

For someone living with chronic illness, this might look like preparing to meet a friend for dinner, only to have symptoms flare at the last minute. A healthy hippocampus would remind you: “This is just a temporary setback, I’ve gotten through this before.” But when stress and inflammation disrupt its function, the brain instead pulls forward old memories of canceled plans, embarrassment, or fear of letting others down. The result is a loop where the past overshadows the present, and your body reacts as though the disappointment is happening all over again.

Together, the amygdala and hippocampus shape how we process emotions, store memories, and respond to stimuli. When the amygdala is overactive and the hippocampus is under-functioning, the brain struggles to distinguish between past and present. This can lead to a kind of neurological “time warp,” where old wounds feel vividly current and the body remains in survival mode long after the threat is gone. This imbalance also creates a negative memory bias, where the brain unconsciously prioritizes threat-based interpretations to protect you, even when they’re no longer helpful.

But the good news is this: healing begins when we teach the brain a new story.

Brain retraining helps restore balance between these regions. It calms the amygdala, supports hippocampal recovery, and creates new neural pathways grounded in safety, connection, and presence. Over time, the brain can learn to respond to life with more flexibility and less fear and recognize that you are safe now.

The ABC Dimensional Shift Technique

  1. A) Awareness
    Notice when you’re caught in a stress loop. Maybe your thoughts are racing, your breath is shallow, or your jaw is tight. This is your cue. Recognizing the pattern is the first step in breaking it.
  2. B) Body Presence
    Ground yourself in the here and now. Feel your feet on the floor. Take a few deep, intentional breaths. Gently name your state: “I feel anxious right now” or “My body feels tense.” Bringing mindful attention to your physical sensations helps re-anchor the nervous system in the present.
  3. C) Choice
    Here’s where you shift the loop. Choose a new signal of safety, something that evokes calm. This could be visualizing a peaceful place, recalling a comforting memory, listening to soothing music, or engaging in light movement. You’re not pushing the fear away; you’re showing your brain a new, regulated experience to attach to instead.

These ABC shifts only take a few minutes, and when practiced consistently 2 to 4 times a day, they start to reshape your brain’s default settings. Think of it like strengthening a muscle. The more you practice, the easier and more automatic it becomes for your nervous system to return to safety.

At first, it might feel subtle or even awkward; that’s normal. But over time, you’re building a new internal rhythm. Each shift tells your brain, This is what calm feels like, and with repetition, it starts to believe you.

The Power of Self-Compassion

Your perception can change your biology. Studies show that shifting from fear to compassion can influence gene expression and reduce inflammation. When we meet ourselves with curiosity instead of shame, we make space for deep healing.

Rewiring Is a Daily Practice

Brain retraining is not about quick fixes. It’s about consistently offering your brain new information that supports regulation and safety. You are not trying to override your symptoms. You are helping your nervous system learn a new way to respond.

If visualization feels difficult at first, begin with your senses. Play calming music, smell a familiar scent, feel the warmth of sunlight, or focus on a grounding texture. These simple cues can gently guide your brain out of a stress response and into a more present, safe state.

In real life, this might look like feeling anxious before a social event. Instead of spiraling, you place a hand on your chest, take a deep breath, and say, “It’s okay to feel this. I can choose calm.” Or when a symptom flares, you remind yourself, “This is a stress response. I’ve felt this before, and I know it passes.” Medical fears- MRI, presentation 

Waking up with dread? Try putting your feet on the floor and taking three slow breaths. Let natural light in, or step outside for a moment. When critical thoughts show up, meet them with curiosity. Ask, “What do I need right now?” or say, “I’m doing the best I can.” 

If you’re overwhelmed by too many tasks, pause. Choose one thing. Take a simple action like drinking water or stretching. Tell yourself, “One step is enough.”

These daily practices may seem small, but over time, they build new neural pathways. Just like a muscle strengthens with use, your brain becomes more flexible and resilient the more you practice returning to calm and presence.

Why Brain Retraining?

Your brain’s threat detection system, which includes the amygdala, hippocampus, and prefrontal cortex, was designed to protect you. These regions work together to detect danger, process memories, and make decisions that help you stay safe. However, under prolonged stress or past trauma, this system can become hypersensitized and get stuck in a chronic state of defense. When the brain stays on high alert, it begins to perceive even neutral experiences as potential threats.

This kind of chronic activation can manifest in many ways. You might experience persistent hypervigilance, where your body and mind remain tense or on edge. Over time, this wears down your energy reserves, leading to deep fatigue and burnout. Many people also become more sensitive to things like certain foods, supplements, or environmental stimuli that didn’t previously bother them. Emotional symptoms like anxiety or mood swings may surface, alongside physical ones such as pain amplification or hormonal imbalances.

Retraining these neural loops through somatic practices, vagus nerve toning, and nervous system support helps shift the body and brain out of survival mode, creating space for healing and restoring a sense of safety. This is an essential foundation for individuals living with chronic illness or stress-related conditions.

Conditions That Benefit from Brain Retraining

These practices help shift the body from defense mode to healing mode, a crucial transition for clients dealing with:

  • Chronic Fatigue Syndrome (CFS): marked by unrelenting exhaustion that isn’t relieved by rest, along with brain fog, sleep disturbances, and post-exertional malaise, where even minimal activity leads to a crash.
  • Autoimmune flares (Hashimoto’s, Multiple Sclerosis, and others): Symptoms may include joint pain, fatigue, brain fog, temperature dysregulation, and heightened sensitivity to stress or environmental changes
  • Mold and Chemical Sensitivities (Mycotoxin illness, MCS): Often show up as headaches, dizziness, sinus congestion, fatigue, skin rashes, breathing difficulties, and neurological symptoms triggered by everyday exposures like perfume, cleaning products, or water-damaged buildings.
  • Histamine Intolerance / Mast Cell Activation Syndrome (MCAS): Symptoms can include flushing, hives, itching, rapid heartbeat, headaches, nausea, anxiety, and food or temperature sensitivities that seem to come and go unpredictably.
  • Environmental Illness and Toxicity (Heavy Metals, Pesticides, etc.): May cause cognitive dysfunction, fatigue, irritability, tingling or numbness, digestive distress, and a general feeling of being unwell without a clear diagnosis.
  • Unidentified Chronic Conditions: Many clients experience clusters of symptoms like bloating, constipation, food sensitivities, rashes, anxiety, insomnia, or a general sense that their body is stuck in overdrive, yet labs come back “normal.”

In all of these cases, the nervous system often becomes hypersensitive and stuck in a loop of hypervigilance. Brain retraining helps calm the overactive limbic system, rewire stress patterns, and support the body’s return to a state of homeostasis.

Introduction to Somatic Movement 

Brain retraining works top-down, while somatic movement heals from the body up by restoring the brain–body connection. Mindful practices such as yoga, Tai Chi, dance, or gentle movement help regulate the nervous system, release emotions, and support detoxification. Chronic stress can cause sensory motor amnesia, meaning the body “forgets” how to move freely. Somatic movement reawakens natural rhythms and pendulation, the cycle of expansion and contraction that is vital for regulation and resilience. Starting with trauma-informed videos or gentle classes allows you to tune into body sensations, honor your limits, and avoid pushing through pain. Over time, these practices create a safer, more resilient foundation for lasting emotional and physical healing.

Brain retraining and somatic practices aren’t new. Throughout history, humans have rewired their nervous systems through meditation, breathwork, chanting, prayer, and community rituals, practices that cultivate calm, balance, connection, and healing. What’s changed is that modern neuroscience, trauma-informed care, and neuroplasticity research now provide frameworks that explain why these techniques are so effective, giving us the language and tools to apply them with greater precision

You Are Not Broken

Illness and stress-related conditions do not mean you are broken. Your brain and body have been doing their best to protect you, even if those patterns no longer serve you. With gentle retraining and somatic practices, you can guide your nervous system back to balance, safety, and resilience. Healing is not about fixing what is wrong with you; it’s about remembering your body’s innate ability to restore itself. With consistent practice, you can feel calm, joy, and vitality again. Your biology is adaptable, and your healing is not only possible but inevitable. Most importantly, you are not broken; you are your own best healer.

Ready for a Shift?

Book a 15-minute discovery call to explore how we can support your healing through nutrition, nervous system regulation, and brain retraining practices.

While this all may seem overwhelming on your own, working with a registered dietitian is the best place to start to find the root of your symptoms! Schedule a free 15-minute nutrition strategy call to discuss the best approach for you! This is the very first step before beginning the initial “Comprehensive Root Cause Analysis” appointment. Working with a skilled Kalish Method Practitioner, detoxification specialist, and functional medicine dietitian is essential in developing an individualized plan for long-lasting success!

 

02Nov

Creating a Healing Terrain For The Vagus Nerve

Creating a Healing Terrain For The Vagus Nerve

 

Healing is more than addressing lab markers or optimizing nutrients. It’s about restoring safety to the body on a cellular level.

Functional lab testing and personalized nutrition are powerful tools. They help us identify root causes, target deficiencies, and tailor protocols with precision. For some clients, this targeted support is enough to create significant change. But for many others, there’s still something missing: a sense of internal safety.

Nutrition addresses the biochemical side of healing. What often goes unaddressed is the electrical side: the nervous system’s tone, signaling, and ability to shift out of defense mode. When we integrate vagus nerve toning and brain retraining into a personalized, lab-informed plan, we begin to create a true healing terrain. This foundational wellness allows the body to move from survival into repair.

In this state, nutrients are better absorbed, inflammation quiets, hormones recalibrate, and cellular healing activates. The body is no longer stuck in defense. It begins to remember how to restore balance. This is when true transformation happens: not just symptom relief, but lasting homeostasis, resilience, and vitality.

In our recent post, we explored the Cell Danger Response (CDR)—a protective metabolic reaction our cells initiate when faced with physical, emotional, or environmental threats. When the CDR becomes chronically activated, the body remains stuck in a loop of defense, impairing mitochondrial function, gut health, and immune balance. This disruption can block the natural healing cycle, impairing mitochondrial function, gut health, and immune balance, blocking natural healing, known as salugenesis.

What happens after infections are cleared, nutrient levels are replenished, gut imbalances are corrected, and the body still doesn’t feel safe enough to heal?

That’s where nervous system regulation and vagus nerve activation come in.

The Missing Link in Healing: Nervous System Healing Starts with Safety

Several individuals with chronic illness face an invisible hurdle: their nervous system has been wired for survival for so long, it doesn’t remember how to rest. This chronic state of fight-or-flight isn’t just a psychological issue; it’s a physiological pattern. And unless we address it directly, healing may be impossible.

This is why we view nervous system work as the foundation of healing, not a replacement for nutrition and lab-based care, but the grounding that allows all other interventions to truly work.

When the nervous system is regulated, clients often experience better digestion, balanced hormones, stronger immunity, and greater tolerance to treatment. These improvements occur because the body shifts out of survival mode and into a state where healing becomes possible.

Chronic stress follows a predictable loop: alarm (fight or flight), resistance (pushing through), and eventually exhaustion, where chronic symptoms emerge. This isn’t just psychological; it’s deeply embedded in the limbic system and autonomic nervous system. Left unaddressed, this loop can drive inflammation, fatigue, digestive issues, and hormonal imbalances.

The key to breaking this cycle? Rewiring the brain’s response to stress and restoring a sense of safety in the body.

The Role of Brain Retraining

Brain retraining programs, such as Primal Trust or the Dynamic Neural Retraining System, work by rewiring neural pathways that have been shaped by chronic stress, trauma, or illness. These patterns can cause the brain to continually scan for danger and overreact to stimuli, including foods, supplements, people, or even benign environments.

Your Healing Can Become “Stuck”: Why Vagus Nerve Toning Matters

The vagus nerve is one of the most important communication pathways between your brain and body. When stimulated, it activates the parasympathetic nervous system, your body’s “rest, digest, and heal” mode. This activation helps regulate everything from digestion and inflammation to mood, sleep, and heart rate. Daily vagus nerve exercises can support your body’s ability to bounce back from stress and restore balance at the cellular level.

Think of vagus nerve toning like strength training for your nervous system. Just as physical strength requires consistent effort, easing chronic stress takes regular practice. Even 15 to 20 minutes a day can make a big difference. Over time, you teach your body to return to calm and connection more easily, creating nervous system muscle memory.

You can stimulate the vagus nerve in many ways. Gentle humming or chanting activates the vocal cords, which improves vagal tone. Splashing cold water on your face triggers a parasympathetic response. Gargling, heart-focused breathing, and slow grounding movements also help release stress and shift the body from threat to safety.

These techniques work by releasing stored stress and shifting your body’s internal state from a place of perceived threat to one of safety and trust.

Breathwork: VU Breathing Technique

One of the simplest and most effective ways to tone the vagus nerve is through breathwork. Slow, deep belly breathing signals safety to the body and shifts you out of fight-or-flight mode. A practice is called the VU Breathing Technique, sometimes called the “Breathifier” method.

Begin by inhaling deeply through your nose into the lower abdomen, allowing the diaphragm to fully expand. As you exhale, create a low, vibratory “VU” sound—similar to a long hum in the back of your throat, like a foghorn. Repeat this cycle for two to five minutes while seated or lying down in a calm space.

It might feel unusual at first, especially making the vocal sound, but with practice, it will feel natural. Over time, this practice can help stimulate the parasympathetic nervous system, induce calm, and support emotional regulation and nervous system balance.

 

HeartMath and Heart Rate Variability Training: Tuning the Heart-Brain Connection

Heart Rate Variability, or HRV, is the natural variation in time between heartbeats. A healthy heart does not beat evenly but adjusts constantly to your internal and external environment. High HRV shows nervous system flexibility and resilience, while low HRV may signal chronic stress, fatigue, or inflammation.

The HeartMath technique helps increase HRV by combining breathwork with emotional self-regulation to create “coherence,” a state where the rhythms of your heart, breath, and brain align. This promotes healing, focus, and emotional balance.

To practice, focus on the area around your heart and breathe slowly, inhale for five seconds, exhale for five. Think of a positive feeling like gratitude or love. Start with one to three minutes daily and increase gradually.

This practice calms the nervous system, lowers cortisol, supports hormone balance, and strengthens the heart’s electromagnetic field, improving both your inner state and connection with others.

Why HeartMath and HRV Training will lead to healing

Heart-focused breathing, like HeartMath or HRV biofeedback, is a powerful tool for regulating the nervous system. Start with one to three minutes daily and gradually increase as you become comfortable. These practices create harmony between the heart and brain, calming the nervous system, reducing reactivity, and boosting HRV, which is a key marker of stress recovery. They also lower cortisol and support healthy DHEA levels, linked to energy and resilience.

Consistent practice enhances the heart’s electromagnetic field, influencing both internal physiology and emotional state. Over time, it aids emotional regulation, promotes healing, and reshapes stress responses. Benefits include improved calm, energy, sleep, and resilience to anxiety, trauma, and chronic illness. It also supports cardiovascular and immune health and offers real-time tracking through HRV devices.

Eye Gaze Stabilization involves fixing your gaze on a stationary object while slowly turning your head side to side or up and down. This strengthens the vestibulo-ocular reflex, stabilizing vision during movement by improving coordination between your inner ear and eyes. It reduces dizziness, motion sensitivity, and improves balance while gently activating the brainstem to help regulate overstimulation. It’s useful during brain fog, after screen fatigue, or when feeling ungrounded.

Pursuit Eye Tracking means following a moving object, like your thumb or a pen, with your eyes while keeping your head still. This engages the cerebellum and frontal cortex, improving attention, visual tracking, and executive function. It’s especially helpful for anxiety, ADHD-like symptoms, or recovery from stress. Use it in the morning, before focus tasks, or during breaks to calm and refocus.

Near-Far Gaze (Accommodation Shifts) alternates your focus between a close object (like your finger near your nose) and a distant one (across the room). This trains your brain to shift focus efficiently, promotes neuroplasticity, reduces eye strain, and improves depth perception. Use it to relieve screen fatigue, before or after breathwork, and to reconnect with your surroundings.

Vagus nerve stimulation reduces stress by activating the parasympathetic nervous system, lowering cortisol, calming heart rate, and building resilience. It improves nervous system regulation and vagal tone, supporting emotional stability and reducing reactivity. It also enhances digestion and immunity by boosting gut motility, reducing inflammation, and strengthening immune response, which helps with issues like bloating or constipation. Overall, a regulated nervous system promotes hormone balance, detoxification, and cellular repair, creating the foundation for lasting healing.

Creating a Healing Terrain

When vagus nerve toning and brain retraining are layered into a root-cause nutrition and lab-based protocol, we create a healing terrain, one that supports both the chemistry and the electrical wiring of the body. This is when transformation happens, not just symptom improvement, but a true restoration of homeostasis.

If your healing has plateaued despite doing “all the right things,” it may be time to consider nervous system work as the missing link.

At 23 Nutrition Therapy, we guide our clients through this integrative approach, blending evidence-based nutrition with nervous system regulation so the body feels safe, supported, and ready to heal.

From CDR to Trust-Based Healing

The Cell Danger Response reveals how stress disrupts mitochondrial and immune function. But unless we address how the brain and nervous system store that stress, we risk staying stuck in survival, even after we’ve addressed the physical root causes.

What often keeps people stuck is the unprocessed stress stored in the brain and nervous system. Unless we address this component, the body may continue to operate as though it’s under threat, even if lab markers improve or symptoms temporarily ease. For those with high-achieving, Type A, or perfectionist tendencies, this is especially important. These individuals often push through discomfort, override body signals, and internalize high stress as “normal.” They may hold themselves to impossible standards and struggle to rest, slow down, or trust the healing process. Ironically, these very traits, while often praised in our culture, can make it harder for the nervous system to shift out of fight-or-flight and into a state of repair.

This is why our approach at 23 Nutrition Therapy combines functional nutrition testing and molecular therapies with brain retraining and nervous system healing. We work with tools that address not just the biology, but also the lived experience of stress, helping the body re-establish a felt sense of safety. Because when we combine these modalities, we’re not just managing symptoms or checking boxes, we’re creating the conditions for the body to remember how to heal.

Stay tuned for Part 2: Rewiring Your Brain

In the next post, we’ll explore how memory, stress, and trauma shape our neural pathways and how brain retraining techniques like the ABC Dimensional Shift can help rewire your nervous system and unlock long-term healing.

Ready to Rewire Your Healing?

If you’ve addressed the root causes but still feel stuck, your body may not feel safe enough to heal. Let’s set you up with the tools to feel safe again.

Book a free 15-minute strategy call to explore how nutrition, vagus nerve training, and brain rewiring can support your healing journey.

While it can be overwhelming trying to navigate this on your own,  working with a skilled Kalish Method Practitioner, detoxification specialist, and leap certified functional medicine dietitian is essential in developing an individualized plan for long-lasting success! The very first step before beginning the initial “Comprehensive Root Cause Analysis” program is to schedule a free 15-minute nutrition strategy call to discuss the best approach for you!

 

06Jun

Understanding the Cell Danger Response (CDR): How Stress Affects Your Health and Healing

At 23 Nutritional Therapy, we explore how our bodies respond to stress. A key process in healing is understanding the Cell Danger Response (CDR), a concept proposed by Dr. Robert Naviaux, MD. This metabolic response protects cells under stress. Understanding this process can offer profound insights into the root causes of disease, chronic illnesses, mental health issues, and even developmental disorders.

In this blog, we’ll explore what the CDR is, how it impacts your health, and how we can support our bodies to heal, leading to foundational wellness.

Innate Intelligence Activates the Cell Danger Response 

What is the Cell Danger Response (CDR)? The CDR is a natural protective mechanism triggered by chemical, physical, or biological stressors. When overwhelmed, the body shifts its inherent metabolic processes, affecting:

  • Oxidation and reduction cell reactions
  • Mitochondrial function 
  • Lipid metabolism
  • Protein folding 
  • Cell membrane fluidity
  • Vitamin bioavailability
  • Homeostasis

When the CDR Goes Awry: Chronic Disease Develops

Cells rely on a balance between oxidation and reduction reactions to produce energy and function properly. Oxidation means losing electrons, while reduction means gaining them. These reactions power mitochondria, which convert nutrients into energy. Normally, cells produce small amounts of reactive oxygen species (ROS) that aid in signaling and immune defense. But under stress from toxins, infections, or inflammation, ROS levels can rise sharply, causing oxidative stress.

In response, cells enter defense mode and increase ROS production to fight damage. While helpful in the short term, excessive ROS harms proteins, DNA, and mitochondria, disrupting energy production and causing inflammation. When the threat passes, antioxidant systems restore balance and support healing.

Dr. Naviaux’s research shows that chronic activation of the Cell Danger Response (CDR) blocks the body’s natural healing process, known as “salugenesis.” This leads to metabolic dysfunction, gut imbalances, autoimmune diseases, and neurological issues, including:

  • Chronic Fatigue Syndrome (CFS)
  • Autoimmune diseases
  • Gut microbiome imbalances
  • Behavioral and neurological conditions like ADHD

Persistent stress signals stored in metabolic memory keep cells stuck in defense mode, preventing recovery. Addressing root causes, not just symptoms, is essential for long-term healing. Supporting mitochondrial health and reducing oxidative stress helps the body exit chronic CDR activation and resume natural repair.

The Healing Cycle: A Natural Process of Recovery

The body’s healing cycle follows a structured sequence to ensure recovery after injury. 

This cycle consists of three main stages:

  1. Initial Injury Response (Acute phase): The body uses external energy and medical interventions, like surgery or medication, to repair trauma (e.g., gunshot wounds, heart attacks, or infections).
  2. Recovery Phase (Chronic phase): Key modalities in functional medicine that unblock healing

Harnessing Molecular Therapies & Functional Nutrition for Healing

Functional nutrition testing and molecular therapies play a key role in restoring balance by addressing deficiencies, eliminating triggers, and supporting mitochondrial function.

Molecular Therapies:

Molecular therapies begin with targeted nutrient therapy, which utilizes specific vitamins, minerals, and antioxidants to repair cellular damage, support detoxification pathways, and enhance mitochondrial function, where our cellular energy is produced. These nutrients are fundamental in restoring balance, improving energy levels, and boosting resilience. Functional nutrition testing provides deeper insight into the body’s needs, identifying and correcting common nutrient deficiencies such as magnesium, vitamin D, B vitamins, and trace minerals that are essential for metabolism and overall vitality.

In tandem, food sensitivity testing helps uncover inflammatory foods that may be contributing to chronic symptoms. From there, a personalized healing plan can be crafted with guidance from a functional medicine dietitian. To further support systemic healing, gut health analysis evaluates for signs of dysbiosis, leaky gut, or microbial imbalances; factors that often go undetected but have significant impacts on immunity, digestion, and inflammation.

Eliminating ongoing triggers is another critical step in the healing process. This includes addressing environmental toxins and heavy metals through targeted detox strategies and lifestyle modifications. Infection management is equally important; chronic or latent bacterial, viral, fungal, or parasitic infections can drive low-grade inflammation and worsen symptoms if left unaddressed.

“Restoring energy begins at the cellular level… mitochondrial functioning is essential for longevity!”

Nutrients such as CoQ10, acetyl-L-carnitine, alpha-lipoic acid, and magnesium are known to fuel mitochondrial efficiency and reduce fatigue. Alongside this, mitochondrial-targeted movement and exercise protocols improve circulation, enhance energy production, and stimulate mitochondrial biogenesis, promoting endurance and overall vitality.

Finally, the foundation of long-term healing lies in food. A diet rich in anti-inflammatory ingredients, like omega-3 fatty acids, turmeric, ginger, leafy greens, and high-quality, bioavailable protein, helps calm the immune system and reduce flare-ups. Nutrient-dense foods such as grass-fed meats, wild fish, bone broth, fermented foods, and organic vegetables provide the essential building blocks for cellular repair and immune function, bringing the entire healing protocol full circle.

Long-Term Healing and the Remodeling Phase

As the body begins to stabilize, it naturally redirects energy and resources toward deeper healing, repairing tissues, optimizing function, and restoring balance. This long-term remodeling phase is where foundational improvements give way to lasting change, especially when addressing complex or lingering conditions like SIBO, IBS, and chronic constipation. A key player in this stage is the migrating motor complex (MMC), a critical yet often overlooked aspect of digestive motility. When the MMC isn’t functioning properly, it can contribute to bacterial overgrowth, sluggish digestion, and recurring symptoms. 

To uncover root causes and guide this next level of healing, Functional Diagnostic Nutrition Lab Testing becomes essential. These advanced tests provide insight into hidden imbalances and help build a more personalized protocol:

Comprehensive Stool Testing identifies dysbiosis, leaky gut, enzyme deficiencies, parasites, and pathogens, all of which are underlying root causes of symptoms like bloating, brain fog, and irregular bowel patterns tied to SIBO or IBS.

Food Sensitivity Testing helps pinpoint dietary triggers driving chronic inflammation, allowing for the creation of a tailored, anti-inflammatory nutrition plan.

Micronutrient Testing highlights deficiencies in key vitamins and minerals, such as B vitamins, magnesium, and vitamin D, which are crucial for gut health, immune support, and nervous system balance.

Hormone and Adrenal Testing evaluates cortisol rhythms, thyroid status, and sex hormones to assess how stress and endocrine health may be impacting digestion and systemic healing.

During the remodeling phase, the body’s innate intelligence activates the cell danger response—a protective mechanism that, when properly supported, helps shift the body from survival mode to restoration. With the right tools, long-term healing becomes sustainable. Understanding mitochondrial states shows how stress affects cellular healing: chronic stress or infections can lock mitochondria in a pro-inflammatory (M1) state, blocking recovery. Supporting mitochondrial health encourages a shift to the anti-inflammatory state, promoting effective healing and regeneration.

Mitochondria, Stress, and Healing: The Key Connection

  • Uncommitted (MO) State: In this baseline state, mitochondria focus on supporting cell growth, maintenance, and biomass replacement. This mode allows cells to function normally and regenerate tissue under healthy, low-stress conditions. It represents a state of readiness where mitochondria provide energy efficiently without triggering immune responses.
  • Pro-inflammatory (M1) State: When cells encounter acute stressors such as infection, injury, or toxins, mitochondria shift to the M1 state. Here, they generate reactive oxygen species and release inflammatory signals to activate immune defenses. This form is critical for fighting off pathogens and clearing damaged cells, but prolonged activation can lead to chronic inflammation and impede healing.
  • Anti-inflammatory (M2) State: After the immediate threat resolves, mitochondria move into the M2 state to promote healing and repair. In this mode, they help reduce inflammation, support tissue regeneration, and restore normal cellular function. The M2 state is essential for resolving the Cell Danger Response and allowing the body to return to homeostasis.

Stress and Environmental Triggers: Why People Stay Chronically Ill

In today’s world, toxic environments and hidden stressors pose a constant challenge to our well-being. Even with an organic diet, environmental contamination can silently sabotage the body’s healing process, keeping many people stuck in cycles of chronic illness. 

Common Stressors That Impact the Healing Cycle

The healing cycle can be disrupted by many hidden stressors that strain the body’s cellular systems. Biological factors like hidden infections (Lyme disease, Epstein-Barr Virus, HHV6), fungal overgrowth from mold toxins, and other microbial invaders keep the immune system constantly active. Chemical toxins from pesticides, plastics, heavy metals, and pollutants quietly impair mitochondrial function and cell signaling. Physical trauma, whether from acute injuries or unresolved chronic damage, can lock the body in a defensive state. Emotional and psychological trauma, including grief, financial stress, early childhood neglect, or ongoing chronic illness, also traps the nervous system in survival mode, preventing effective healing and restoration. 

Understanding CDR symptoms is key, not just for symptom management but for uncovering the root cause of disease, keeping the body trapped in a stress-response state. This is where the Cell Danger Response (CDR) becomes crucial: when the body is stuck in survival mode, it can’t return to healing. Recognizing and addressing CDR patterns is essential for resolving the deeper dysfunction driving chronic illness.

Why Can’t We Heal?

For individuals with chronic illness, healing is often blocked by continuous reinjury. Whether from unresolved infections, ongoing exposure to toxins, or psychological trauma, the body’s ability to recover is hindered. Understanding your adrenal stress hormone response and its relationship with the cell danger response can be key to unlocking your healing potential. Functional nutrition testing and functional diagnostic nutrition lab testing can help pinpoint underlying imbalances and identify the right interventions to remove these blocks.

Unblocking the Healing Cycle: A Path to Wellness

To unlock the healing cycle and support recovery, we must focus on:

  1. Removing Triggers: This may include eliminating toxins from your diet or environment, addressing infections, or reducing emotional stress.
  2. Supporting Cellular Healing: Through functional nutrition, we can provide the necessary nutrients to support mitochondrial health, improve gut health, and reduce inflammation. Our bodies possess an incredible ability to heal, and functional nutrition plays a crucial role in this process. By providing the necessary nutrients, we can support mitochondrial health, improve gut function, and reduce inflammation.

Encouraging Regeneration

True healing requires more than just removing triggers; it also involves creating the right internal environment for regeneration. One essential area to support is digestive function, particularly by encouraging the Migrating Motor Complex (MMC). The MMC is a critical part of our digestive system’s housekeeping mechanism, helping to clear residual food, bacteria, and debris from the small intestine between meals. Stimulating the MMC can be especially helpful for individuals dealing with Small Intestinal Bacterial Overgrowth (SIBO) and chronic constipation, both of which often arise from impaired gut motility.

In addition to digestive support, reducing stress and regulating the nervous system are equally important for restoring the body’s natural healing rhythm. Chronic stress can interfere with gut function, immune response, and cellular repair. Programs like Primal Trust™ and DNRS™ (Dynamic Neural Retraining System) are designed to shift the body out of a survival-based stress response and into a parasympathetic state, where regeneration and repair can occur. These brain retraining techniques work by helping the brain rewire maladaptive stress patterns, supporting nervous system resilience and creating the safety signals the body needs to return to homeostasis.

A Journey to Wellness

The Cell Danger Response (CDR) is the body’s natural defense mechanism against stress, but when stuck in this mode, it can block healing and contribute to chronic illness. By addressing root causes, supporting mitochondrial function, and fueling your body with a nutrient-dense diet, you can help shift out of survival mode and into lasting, foundational wellness.

 

If you’re feeling stuck or dealing with chronic symptoms, let’s connect for a free 15-minute nutrition strategy call to begin exploring your wellness journey.

Sources:

  • Naviaux RK. Metabolic features and regulation of the healing cycle-A new model for chronic disease pathogenesis and treatment. Mitochondrion. 2019 May;46:278-297
  • Naviaux RK. Metabolic features of the cell danger response. Mitochondrion. 2014 May;16:7-17.
  • https://www.primaltrust.org/about/
  • https://retrainingthebrain.com/
02Feb

The Real Root Cause of Your Hormone Imbalance Brain Fog, Adrenal Fatigue, and Digestive Symptoms: Part 1

You’ve just left your doctor’s office with as many questions about your symptoms as when you walked in. During your consultation, you felt rushed, and your symptoms were minimized to a general diagnosis. Next, your clinical lab results came back, and everything was “normal.” However, YOU know there is something wrong. The real question is what is conventional medicine offering you?

In conventional medicine, doctors are trained to treat symptoms. This approach disregards the root cause of disease and how chronic illnesses develop. Functional medicine addresses the three foundational body systems — the neuroendocrine system, the digestive system, and the liver detoxification system. Addressing these 3 body systems will help you correct metabolic imbalances related to adrenal fatigue, anxiety, sleep disturbances, digestive issues, leaky gut, and brain fog.

If you’re at a dead-end and sick of the band-aid approach, dive into this 3 part blog series to understand what’s at the root of your symptoms.

Foundational Wellness
The Gut-Hormone-Detox System

The gut, brain, and liver work together to keep the body in a state of homeostasis aka balance. When an organ is not functioning optimally, imbalances of biological systems occur within the gut-hormone-detox system (neuroendocrine system, digestive system, and liver detoxification system). The neuroendocrine system, mainly controlled by the brain, regulates neurotransmitters and stress hormones, which affect sex hormones, thyroid hormones, and mitochondrial energy metabolism.

The large intestine includes the gut microbiome, which is home to many beneficial bacteria. It is essential to have a healthy gut mucosal lining because it serves as a protective barrier, keeping pathogens from entering the body and causing leaky gut. A leaky gut may put you at a higher risk of developing GI disorders – Small Intestinal Bacterial Overgrowth (SIBO) and Irritable Bowel Syndrome (IBS). 

Detoxification takes place in the lungs, digestive system, kidneys, and skin. However, the majority of detoxification occurs in the liver. There are gene variants that influence enzymes, antioxidants, and nutrient cofactors. Toxins are filtered by enzymes, and keep the body free from harm. 

What happens when one of these three foundational body systems is out of balance? In part one of this blog series, we’ll be diving into the neuroendocrine system and its connection to the root causes of your health concerns. 

The Neuroendocrine System

The neuroendocrine system guides the production of hormones (stress, sex, and thyroid) and neurotransmitters (catecholamines, dopamine, and serotonin) and can be tested through nutrigenomic testing. The production and processes of these hormones/neurotransmitters are largely dependent on lifestyle, diet, and nutritional genetics. This is called Neuro Nutrition

Mitochondrial Markers and Neurotransmitters on the Individual Optimal Nutrition Test ION

These two tests are used by functional medicine dietitian, Gayatri at 23 Nutrition Therapy to measure neurotransmitter metabolites: the Organix Organic Acid Test (OAT) or the Genova ION Test. Despite the OAT providing an Organix comprehensive profile,  the ION test is more comprehensive than the OAT and involves a urine sample and a blood draw. You can also review the sample report for the ION test here.  

There are over 150 biomarkers in the ION Test, with two critical mitochondrial energy markers: adipate and suberate. These organic acids are necessary to convert fatty acids to energy, using the help of an amino acid, L-carnitine. When these markers are high, it is possible that there is an L-carnitine deficiency, which means your body does not have the ability to break down stored fatty acids and convert them into energy thus leading to fatigue and difficulty with weight loss. These markers also help us understand if there is an energy deficit leading to a mitochondrial deficiency which can cause thyroid function impairment. 

Hormones of the Neuroendocrine System

Hormones are the body’s chemical messengers that travel through the bloodstream to various organs and tissues. Hormones are responsible for development, metabolism, growth, reproductive function, and mood. High amounts of stress hormones tax the adrenal glands, which are part of the neuroendocrine system. High levels of stress hormones may stem from external stressors that come with life’s unpredictable events, but there are internal stressors such as infections, gut pathogens, molds, and exposure to heavy metals. 

Internal and external stressors can impact the production of the hormones cortisol and DHEA, which are released by the adrenal glands. Cortisol is a catabolic hormone, meaning it breaks down components in the body, often during times of stress or “fight-or-flight”. Dehydroepiandrosterone, or DHEA, is an anabolic hormone that repairs damaged cells in the body during times of growth. When the body is presented with high levels of long-term chronic stress, the production of cortisol and DHEA is impacted thus more cells are being broken down and less damaged cells are being repaired. Both of these hormones are released from the adrenal glands and play a crucial role in maintaining homeostasis (balance). 

Have you ever heard the saying, “You can’t control life’s stressors, but you can control your response?” Let’s break this down.

Our bodies have a built-in mechanism to help us respond to stressful situations, using hormone signaling between the hypothalamus in the brain, the pituitary glands, and the adrenal cortex. Under long-term chronic stress, the hormone signaling communication network between organs and glands starts to malfunction, this is called hypothalamic-pituitary-adrenal (HPA) axis dysfunction and is often mistakenly referred to as adrenal fatigue

Though the adrenals are not fatigued, HPA-axis dysfunction can be compared to losing cell phone signal reception in a basement. This loss of communication impairs your body’s ability to respond to stress and adapt, initiating a catabolic effect on other body systems that ultimately leads to breaking down other cells and tissues and damaging the gut lining.  

HPA-Axis Dysfunction or “Adrenal Fatigue”

HPA-axis dysfunction is commonly mistaken as “adrenal fatigue,”. Symptoms of adrenal fatigue/HPA axis dysfunction symptoms include:

  • Insomnia
  • Weight gain
  • Immune dysfunction
  • Depression
  • Gastrointestinal symptoms
  • Chronic pain
  • Chronic fatigue

Despite the adrenals not actually being fatigued, HPA-axis dysfunction is often mislabeled as adrenal fatigue since the symptoms are similar. Oftentimes, however, it is actually your body’s stress response that is initiating these symptoms, especially in a state of chronic long-term stress.

Physical, emotional, and biochemical stressors influence cortisol and DHEA levels. Potential stressors include working overtime, blood sugar dysregulation from a Standard American Diet (SAD), undereating protein, a sedentary lifestyle, poor digestion, compromised immune function, gut infections, and toxin exposures, combined with a poor ability to detoxify. These all can add up to underperforming HPA-axis signaling and low DHEA levels. 

One of the first steps in assessing your body’s stress response is to test your adrenal hormones through the Adrenal Stress Profile test. The Adrenal Stress Profile is a salivary lab test to assess HPA-axis dysfunction. 

The cortisol awakening response (CAR) marker on the Adrenal Stress Profile, tests for cortisol levels that are present upon waking up. This cortisol level is known as the baseline. Under normal conditions, cortisol elevates to a peak in the morning, about 30 minutes after waking. Elevated cortisol levels give the body energy to transition from a sleep state to an awakened state. Once cortisol levels peak, cortisol returns to baseline about 30 minutes later. 

Another way to assess HPA-axis dysfunction is to monitor DHEA on the Adrenal Stress Profile test.  Low levels of DHEA stem from aging and chronic stress. Diminished DHEA or a low cortisol awakening response, along with disrupted cortisol rhythm throughout the day, tells us how well our HPA axis is functioning.

The Adrenal Stress Profile will assess six points of salivary cortisol samples throughout the day.  This test involves sending saliva samples to the laboratory, this is called salivary hormone testing. Your functional medicine dietitian will look for high and low cortisol patterns, determine if you have HPA-axis dysfunction and what stage it is at, and recommend further treatment protocols.

Three Stages of HPA-axis Dysfunction 

HPA-axis dysfunction is not a linear situation, it develops in stages. After completing an Adrenal Stress Profile, your functional medicine dietitian can begin to stage your HPA-axis dysfunction to personalize your treatment regimen further.

Treatment for stage 1, 2, & 3 HPA-axis dysfunction includes dietary adjustments, emphasizing blood sugar balance, and insulin response. Lifestyle factors, including stress management, exercise modifications, and pain management paired with a personalized therapeutic supplement program prescribed by a functional medicine dietitian will restabilize the HPA-axis.

It is important to note that sleep and circadian rhythms play a huge role in cortisol balance thus for those with sleep disorders/imbalances, those who work night shift, etc.., it is crucial to complete an Adrenal Stress Profile to see if that is the cause of your chronic fatigue. 

What is the Gut-Brain Axis? Gut Neuroendocrine System

The gut-brain axis (GBA) is the communication pathway between the central and the enteric nervous system, which connects the emotional and cognitive centers of the brain with intestinal function. More research is emerging on the importance of gut microbiota in influencing these interactions. One explanation is through the vagus nerve which originates in the brain and ends in the large intestine. 

The vagus nerve stimulates the intestines influencing how food is digested and eliminated. This is known as the migrating motor complex. The vagus nerve also signals the release of digestive enzymes, further promoting food migration through the digestive tract. This function is essential in preventing constipation and increasing nutrient absorption. The vagus nerve can also stimulate the production of stomach acid, which breaks down food in the stomach. If the vagus nerve is compromised, consequences such as indigestion, constipation, and bloating may occur. 

How can you tone your vagus nerve? This includes eating nutrient-dense foods, including a diet high in whole grains and fiber, consuming probiotics, staying hydrated, and limiting the consumption of caffeine. Pointing to the importance of maintaining a healthy gut microbiota, gut dysbiosis has also been linked to compromised immune function.  

Where Do I Go From Here? 

As we continue to see, the systems of the body are all interconnected and highlight the importance of finding the root cause of your symptoms. Working with a skilled Kalish Method Practitioner, gut-hormone-detox specialist, and functional medicine dietitian is essential in developing an individualized plan for long-lasting success! The very first step before beginning the initial “Comprehensive Root Cause Analysis” program is to schedule a free 15-minute nutrition strategy call to discuss the best approach for you!

Stay tuned for part 2 of this blog series where we will continue to discuss the gut-hormone detox system diving into the gut microbiome, digestion, and detoxification![/vc_column_text][/vc_column][/vc_row]

08Dec

Neuro Nutrition: Nutrition Essentials Neuro Clarity

Do you ever feel sluggish, like your mood is all over the place, or generally notice you’re out of whack? A lot of our everyday functioning traces back to how well our brain is working. Neuronutrition is the concept of nourishing ourselves with the nutrients that are going to support our brain health. 

That blob of gray matter between your ears, the brain, is actually the control center for your neurotransmitters. It controls the production of hormones, neurotransmitter communication, metabolism, and many other functions. What helps run these processes? Well, the foods we eat! Food can have a direct impact on the function of our brain. 

It is important that we eat foods that provide us with the proper precursors (inactive substances converted to active ones such as an enzyme, vitamin, or hormone) for the neurotransmitters we require. Proper brain functioning helps us to regulate our three-body systems, as well as functions such as mood, sleep, and metabolism. But what does all this mean and how do you eat for your brain health? Let’s find out.

What Are Neurotransmitters? 

There’s a good chance you’ve heard of neurotransmitters before, even if you have never actually seen this word! Neurotransmitters are brain chemicals created in our body that carry signals across brain cells or neurons. A few commonly discussed neurotransmitters include serotonin, dopamine, and norepinephrine.

Achieving and maintaining the optimal balance of these brain chemicals is essential for our mental health and mood. Food is one of the most direct ways that we can help balance our levels of neurotransmitters; in turn, helping us to regulate our mood, stress, anxiety, and even sleep. 

Key Neurotransmitters and Their Function

Before diving into the important topic of neuro-nutrition, let’s set the stage with some important neurotransmitters you have probably heard of, and their main functions.

  • Serotonin – Aids in regulating sleep/wake cycles and anxiety, mood behavior, appetite, and bowel contractions.
  • Dopamine – Linked to focus, motivation, and pleasure. 
  • GABA – Helps regulate anxiety, stress levels, sleep/wake cycles, and calmness.
  • Norepinephrine – Aids in attentiveness and focus. 

Maintaining and restoring the balance between these neurotransmitters is oftentimes more important than focusing on stimulating a single pathway to produce or inhibit one neurotransmitter because these pathways are so interconnected. Here are a few examples of what different levels of these neurotransmitters can mean for our health: Low levels of serotonin have been linked to depression, anxiety and sleep issues. Excess dopamine can cause cells to experience cell death, or apoptosis, too early. Norepinephrine is commonly referred to as the “fight-or-flight” hormone (often called adrenaline), because it stimulates the sympathetic nervous system and makes us alert to potential danger. As you can see, it is crucial to keep our neurotransmitters in balance for various facets of our health. 

Dopamine and Norephinephrine neuro nutritionFoods For Neurotransmitters 

The neurotransmitters we need are made from the same building blocks as the rest of our cells. Think proteins, fats, vitamins, and minerals. We get these building blocks from our food! Therefore, certain nutrient-rich foods give us an advantage when it comes to building neurotransmitters. This is especially true because our gut actually has an important link to our neurotransmitters and brain health. 

Phenylalanine is an amino acid that is the precursor, aka starting block, to proteins in our body and many of the neurotransmitters we’ve been discussing. We are unable to produce enough phenylalanine on our own, which makes it an essential amino acid that must be obtained through our diet. An essential amino acid means that it is necessary for the production of all the proteins in our body. You’ve heard of the importance of protein intake, and that is because proteins carry out such a wide range of functions in our body. There are antibodies (such as white blood cells), hormones, enzymes, structural proteins (such as collagen), transport/storage proteins (such as ferritin), receptors (such as Vitamin D receptors) and so many more.

Even if we eat “the perfect diet,” our body functions still need to be in tip-top shape for us to reap the benefits of our diet. For example, you need to be able to digest, break down, and absorb nutrients, and then have the micronutrients aka precursors to support cellular pathways.  Phenylalanine is a great example, our bodies convert phenylalanine into tyrosine which is then converted into dopamine through a series of intricate steps (hence why we need our bodies working optimally). Remember we need dopamine, it plays a role in our mood and allows us to find pleasure, focus, and joy. We also require phenylalanine to create norepinephrine, to support our nervous system’s response to stress. 

As you may have noticed, phenylalanine is crucial for maintaining our levels of neurotransmitters in check, which helps regulate so many of our body’s functions. Protein-rich foods such as lean meats, dairy, and legumes all contain phenylalanine. Let’s continue to explore why these foods are so important to include in our diet.  

Neuro Nutrition: Food Sources of Tryptophan

If you’ve ever felt sleepy after a holiday meal, there’s a good chance you’ve heard of tryptophan, another essential amino acid. Tryptophan is found in protein-rich foods such as turkey and chicken. Other good sources of tryptophan include legumes such as chickpeas, beans, and lentils, as well as nuts and seeds. Tryptophan is the precursor to serotonin, remember serotonin is directly tied to our sleep/wake cycles and the production of melatonin.

A high-quality protein-rich diet will supplement us with enough tryptophan to create adequate amounts of serotonin. However, a tryptophan deficiency will not only cause serotonin dysregulation but will also impact all protein functions in the body. This concept is not unique to tryptophan alone, but to all essential amino acids and nutrients, because as we’ve seen before, all of these nutrient pathways are interconnected and affect multiple body functions. If you are experiencing symptoms of anxiety, panic attacks, or sleep dysregulation, it might be beneficial to take an Organic Acids Test, which we will talk more about later. 

 

The Serotonin PathwayNow that we’ve established the importance of adequate protein intake for balancing our neurotransmitter levels, let’s take a look at the other nutrients and vitamins that are crucial for our brain health. 

B vitamins are crucial precursors for building dopamine, melatonin, and other important neurotransmitters. 

There are 7 different B vitamins that are important for our brain health, including vitamins B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B9 (folate), and B12 (methylcobalamin). In addition, getting adequate B vitamin intake from our food is essential for our neurological health. A deficiency of B vitamins can lead to cognitive depletion, such as sluggish thinking, impaired memory, and mood dysregulation. 

Foods that are high in B vitamins include meat, organ meats, legumes, nutritional yeast, eggs, leafy green vegetables, whole grains, dairy, fruit, nuts, and seeds. The key to getting all seven B vitamins is to include a wide variety of these foods in your diet. It is important to note that vegetarians and vegans may have an especially hard time getting enough B vitamins. It’s even more important to watch those levels if you follow a plant-monogamous diet. 

Omega-3 is an essential fatty acid that our bodies cannot produce, so we must get all of our Omega-3 from food. Omega-3 fatty acids are important because they help reduce and prevent inflammation in the brain and body, support cell membranes, improve immune functioning and cardiovascular health, and support our skin health. Fatty fish like mackerel, salmon, and sardines are high-quality essential sources of Omega-3. Marine algae supplements, flax seeds, and chia seeds are also adequate sources of Omega-3. To take a closer look at your omega-3 profile, an ION test might be necessary.

Organix and ION: Tests for neuro nutritionNeurotransmitter Testing: Organic Acids or ION

Organic acids are metabolites or byproducts of cellular processes going on in our bodies.  Examples of these cellular processes include energy production (think ATP and the mitochondria powerhouse of the cells), detoxification, and neurotransmitter breakdown. An Organic Acid test can give us a clue about the efficiency of these processes that are happening inside our body.

In order to get more information about your neurotransmitter levels, an Organic Acids Test can be done. This simple test involves an at-home urine collection upon waking. From there, the urine sample is sent to the lab and tested for metabolite analysis

The Organic Acid Test (OAT) measures 46 different markers of health, including a range of different metabolites of neurotransmitters excreted by our body. The levels of these metabolites are incredibly important as they can indicate levels of certain neurotransmitters, nutrient deficiency, liver detoxification capabilities, and even bacterial overgrowth. 

For more comprehensive results, an Individual Optimal Nutrition (ION) test can be done, this involves a urine sample as well as a blood draw. The ION test is similar to the OAT, but it has 125 markers. To learn more, read about ION nutritional testing here

The results of the Organic Acids Test can provide valuable clues about health issues that may be plaguing you, such as weight issues, sleep abnormalities, and mood dysregulation. An organic acids test provides personalized results that give insight on how to better adjust your diet and supplement regimen in order to support your overall health based on your individual needs. Keep in mind that although intake may be adequate, there could be other factors at play below the surface. These can show up in the Organic Acids Test, which can be used to discover the cause of such issues.

Interested in ordering an Organic Acid Test or Individual Optimal Nutrition Test? Schedule a free consultation call!

Understanding Your Urine Test For Neurotransmitters: Neurotransmitter Balance

Key Neurotransmitters and their metabolites

The Organic Acid Test or ION test will provide you with a comprehensive list of your neurotransmitter metabolite, or breakdown, levels. But it’s quite an extensive list, and it can be confusing, so what do those levels mean? Let’s find out.

Indicators of Brain Stress 

Those experiencing brain stress might be experiencing depression, anxiety, and food cravings and may greatly benefit from stress management techniques, as well as calming herbs and supplements. Some common lab values can include: 

  • Low HVA (Homovanillate)Low levels of HVA can be indicative of inadequate amounts of the precursor phenylalanine or tyrosine. This can be due to inadequate protein intake or a lack of necessary vitamins required for dopamine production. Causes may include chronic stress (adrenal exhaustion), long-term antidepressant usage, inherited amino acid deficiency, many years on a vegetarian or vegan diet, or poor absorption/missing cofactors (necessary vitamins). Symptoms can include fatigue, physical exhaustion, difficulty concentrating, impulsive behaviors, loss of satisfaction, addictions, cravings, and thrill-seeking. Can be linked to Parkinsons’ and ADHD.
  • High HVA (Homovanillate) – High HVA levels suggest that turnover rates of dopamine are too high, which can be caused by excess stress, elevated cortisol, and other stimulants such as caffeine, ephedra, pseudoephedrine, and cocaine.
  • Low VMA (Vanilmandelate) – VMA is a metabolite of epinephrine and norepinephrine and when it is low, it may indicate that norepinephrine or epinephrine are not being produced at adequate levels. This can be associated with adrenal exhaustion, as well as poor protein consumption or absorption. Symptoms may include fatigue, anxiety, inability to deal with stress, sleep disturbances, and depression. 
  • High VMA (Vanilmandelate) – High VMA levels reflect higher than normal turnover and may indicate adrenal stress due to the overproduction of epinephrine or norepinephrine from the adrenals. This can be caused by both internal and external stressors and may feel like the nervous system is overactive. Other symptoms include headaches, anxiety, sleep disturbances, muscle aches, GI disturbances, and high blood pressure. 
  • Low 5-Hydroxyindoleacetate – 5-HIAA is a metabolite of serotonin and is considered to be a happy neurotransmitter. Low 5-HIAA can indicate inadequate production of serotonin. This can be caused by adrenal stress, long-term tyrosine usage, antidepressant usage, poor amino acid intake or absorption, vegan or vegetarian diets, poor absorption or missing cofactors, or inherited deficiency. Symptoms can include depression, anxiety, panic attacks, insomnia, digestive imbalances, constipation, and chronic pain. 
  • High 5-Hydroxyindoleacetate – High 5-HIAA may indicate a higher than normal turnover of serotonin with potential depletion of tryptophan. This can be caused by SSRI use and excess stress.

Indicators of Brain inflammation 

Those experiencing brain inflammation may be experiencing nutrient deficiencies, GI inflammation, stress, and toxin-induced damage to brain cells. This can even be genetic in some cases.  Let’s look at some lab-based indicators too:

  • High Kynurenate – By itself, causes brain inflammation but is indicative of a B6 deficiency in the presence of high xanthurenate. Other causes of elevated kynurenate can include an inflammatory disease state and hidden stress from pathogens in the gut. 
  • High Quinolinate – This may make you feel flu-like. Could indicate an autoimmune disorder, IBS, parasite, or infection. This can be caused by excess inflammation and oxidative stress. Quinolinic acid can be neurotoxic in large quantities. 
  • High Picolinate – This can be caused by excessive protein intake and chronic inflammation.

Additionally, the organic acids test can also measure bacterial and yeast growth with 9 different markers. Bacterial and fungal overgrowth can often be found alongside many health issues. In the case of neuro-nutrition, certain types of bacterial overgrowth can prevent precursors like tyrosine and tryptophan from converting into adequate amounts of neurotransmitters. 

Markers include: 

  • D-Arabinitol – Fungal/Yeast marker 
  • D-Lactate – Bacterial marker
  • 3-4-Dihydroxyphenylpropionate – Clostridium Bacteria Marker

Make sure to fill out a detailed intake form which will be cross-compared to your nutritional test results to give you the best results. To learn more about bacterial overgrowth and how it affects our brain health, order a comprehensive stool analysis.

The Gut-Brain: Gut Hormone Connection   

Good gut hygiene is crucial to remedy neurotransmitter imbalances. After all, if we can’t digest our food properly, none of our body systems will work at their full potential. Interestingly, around half of our dopamine is also produced in the GI tract. Somewhere around 90% of our serotonin is also found in the GI tract and there is evidence that serotonin in the gut aids in peristalsis (muscle contractions that help us digest food). So there might be more to the connection between our gut and our brain than we previously thought. Because of this, it only makes sense that if we want to keep our neural health high, we must look after our gut as well. 

Some tips for keeping the gut healthy include adequate water and fiber intake to help food move. Including probiotic foods in your diet such as kimchi and yogurt can be beneficial. Limiting caffeine is also helpful in maintaining gut health. Read here to learn more about keeping your gut healthy and happy. 

Some other tips for improving our neuro-nutrition include being mindful of our eating patterns, such as meal timing and blood sugar balance, making sure to eat every 3 to 4 hours, and chewing our food well so it is easier to digest.  As you can see, tending to your gut health is an extremely important step to taking care of your neurological health. After all, the food we eat contains the building blocks for our brain cells! If you need a little push in the right direction in terms of neuro-nutrition, schedule a free consultation call with me.

Resources: 

28Nov

The Migrating Motor Complex

Imagine… you’re sitting in class taking an exam, or waiting to be called into a job interview. You’re sitting in dead silence until… your stomach growls. Oh no, did everyone hear that? We’ve all been there! Maybe you haven’t eaten recently because you were cramming for the exam or preparing for the interview. These growling noises are actually the result of the migrating motor complex.

Most people have never heard of this before, so we wanted to dive into this topic to explain what the migrating motor complex (MMC) is, why it’s important, and how to enhance its function.

What is the Migrating Motor Complex?

the migrating motor complex is your guts housekeeper surrounded by cleaning products

The migrating motor complex (MMC) is responsible for moving material through our stomach and small intestine, cleaning house between meals or during sleep.

It is active during fasted states in order to push any undigested residues through the upper GI tract and into the large intestine to prepare a clean slate for your next meal.

This housekeeping role is essential because it reduces the chances of bacterial overgrowth. Without the complete removal of any leftover food within your system, bacteria have a chance to gorge on your meal. This can potentially lead to small intestine bacterial overgrowth (SIBO).

Migrating Motor Complex Stimulation

The MMC has multiple phases with varying strengths of contractions. But what stimulates the contractions to begin with?

The first section of the small intestine, the duodenum, is responsible for regulating the gastric contractions of the migrating motor complex by producing motilin when the duodenum is devoid of food.

3d diagram showing where the duodenum is within the human body

Any nutrients present in the duodenum will suppress the release of motilin, preventing the peak contractions from occurring. This is why spacing out your meals is important – grazing throughout the day can actually halt the migrating motor complex and inhibit it from effectively clearing out your system.

The accumulation of digestive juices in the duodenum increases pressure, which stimulates the release of serotonin. Serotonin further increases the pressure, leading to even more serotonin release, which leads to more pressure, which leads to… you can probably see where this is going!

This positive feedback mechanism reveals that more gastric, pancreatic, and bile secretions are associated with higher migrating motor complex activity. These secretions also aid in cleansing the small intestine by preventing bacteria accumulation. So you can imagine that a lack of any of these secretions could lead to an ineffective MMC and bacterial overgrowth.

The MMC and the Gut-Brain Connection

The vagus nerve is responsible for stimulating the migrating motor complex and supporting normal digestion and elimination. This nerve innervates nearly all of the organs in our torso with parasympathetic (rest and digest) impulses. While sleeping, the vagus nerve is most active because this is the time we are most relaxed and in a parasympathetic, unstressed state.

So you can imagine that when the vagus nerve is inactive, under-stimulated, or damaged, that this can cause a lot of issues with many organs in the body. Stress of any kind can send your body into a fight-or-flight, sympathetic response that deactivates the vagus nerve functions.

This is a huge problem because our bodies were designed to exhibit these stress responses when we encounter threats to our lives – not for the everyday stressors that exist in modern society.

Migrating Motor Complex Disorder

Food poisoning is often a cause of migrating motor complex dysfunction. These pathogenic bacteria that enter the small intestine through the stomach can release toxins that cause damage to the vagus nerve, preventing the MMC from working effectively to sweep material – including the pathogenic bacteria – through your digestive tract. The stasis of food and bacteria in the GI tract can lead to further issues, such as diarrhea, constipation, and SIBO.

Traumatic brain injuries, whether they are as mild as hitting your head on something or as severe as a car accident or concussion, can also be a cause of migrating motor complex dysfunction. Due to the gut-brain connection, any injury to the brain could trigger glitches in the migrating motor complex.

man in gray suit and glasses graping forehead sitting at desk with half open laptop

Chronic stress is another – and possibly the most common – culprit of MMC complications. We all encounter stress in our daily lives… this could be stress from work, relationship problems, or overlapping layers of uncertainties about the future. No matter the source of stress, our bodies are automatically reacting in the same ways – in order to ensure our survival. 

In reality, these responses are maladaptive to our current lifestyles. Most of us aren’t facing a fight to the death with a lion on a daily basis, but our bodies are still responding as if we are! The stress response turns off the vagus nerve and shuts down the migrating motor complex, both of which only work when we are in a relaxed, parasympathetic state.

Most of us spend more time in a sympathetic state than our bodies were designed for, and it directly affects our digestive functions. Any issue in your digestive functioning can cause even MORE stress… and it becomes a vicious cycle.

Tips for Enhancing Migrating Motor Complex Function

1. Space out your meals

fork knife and black alarm clock on white plate on blue wood surface

Since we know that the migrating motor complex slams on the brakes the minute we eat something, it makes sense that spacing out meals would be effective in enhancing migrating motor complex function. This also means that constant snacking is often a no-go if you are experiencing issues with digestion.

Eating one nutritionally balanced meal every 3-4 hours is usually recommended to ensure that the migrating motor complex’s housekeeping roles can be completed before you become hungry again.

Fasting overnight is something most of us do without thinking about, and it’s also something that is critical for optimal digestive function. Not eating between your last meal/snack of the day and breakfast should be relatively simple, because the majority of that time you are sleeping (hopefully!).

Giving your system a 12-hour overnight break from processing foods can guarantee that the migrating motor complex has plenty of time to fulfill its housekeeping duties.

2. Support your stress response

woman in camo yoga pants sitting on dock meditating with headphones

Addressing the stress in our lives is often the first step to eliminating digestive issues. Eliminating certain stressors that you encounter frequently is always a good place to start. However, sometimes it isn’t possible to completely remove a stressor from your life. This is where stress management comes into play.

Things like yoga, mindfulness, meditation, deep breathing, and other relaxation techniques are useful in lowering stress hormones, like cortisol. Training your body with relaxation techniques allows you to more easily get into a parasympathetic state. 

You can also support your stress response by using adaptogenic herbs and following an adrenal supplement protocol in coordination with your functional medicine dietitian. All of these things help tone down stress responses and improve vagus nerve function, leading to better digestion. 

3. Try prokinetics

Prokinetics are supplements that stimulate the migrating motor complex by promoting movement through the digestive system. Prokinetics include supplements such as medicinal bitters, ginger, and 5-HTP. Before taking anything, you should speak with your functional medicine dietitian to figure out the right support you need.

The MMC is essential for clearing out our digestive tract of any undigested materials and bacteria, eventually resulting in their elimination from the body. This process is absolutely necessary to prevent uncomfortable symptoms like gas and bloating, and to avoid more serious problems like IBS and SIBO.

Taking the steps to improve your migrating motor complex function today will help you acquire and maintain a healthy gut and relieve you of any gastrointestinal distress.

 

Schedule your appointment today for personalized tips for improving your gut health!

11Nov

Relaxation Techniques: The Top 4 Types

If you’re reading this, you may be feeling the effects of stress and are seeking some relief! This blog will briefly describe the way our bodies – and our gut – respond to stress, and give you some tools to improve your resilience and overall wellbeing. We will discuss the best types of relaxation techniques for stress reduction.

Humans are not well adapted to the modern world 

stressed woman juggling responsibilities

Every day, we encounter minor mental stressors that our ancestors didn’t have to deal with. They had to deal with the physical threat of fighting predators, while we have to deal with things like long work-weeks, financial worries, adapting to life during a pandemic… These things don’t compare when it comes to life and death, but unfortunately for us, our bodies react the same way to both types of situations.

Our bodies have an automatic response to stress, which our brains perceive as a psychological threat. The brain triggers a cascade of events within the body called the stress response, which way back in the day was meant to ensure our survival. Today, the stress response may be triggered multiple times over the course of the day, keeping our cortisol levels high and leaving us in a maladaptive, sympathetic nervous system state.

The stress that so many of us feel on a daily basis can actually be both physically and mentally harmful. Stress has a HUGE impact on digestion and gut health, and luckily for us, there are steps we can take in order to take back control over our gut health in the midst of a stressful life.

The relaxation techniques listed below can be practiced regularly to give you better control over your reactions to stress. But first, let’s discuss the impact stress has on your gut health.

How does stress impact the gut?

For digestion to function normally, we must be in a relaxed, unstressed state where the parasympathetic branch of the autonomic nervous system is in control. Whenever we experience stress, the automatic stress response activates the opposing branch of the autonomic nervous system – the sympathetic branch.

The sympathetic branch inhibits digestive functions, because they are not essential for immediate survival. This can lead to many digestive problems, especially when stress becomes a recurrent aspect of your daily life – when stress becomes chronic.

So what impact does stress have on the gut? Some symptoms (that you may be quite familiar with) that are commonly experienced due to stress can include diarrhea, constipation, nausea, indigestion, abdominal pain, and heartburn.

man in black and white grabbing stomach highlighted in red

Enough bad news… let’s get to the good news! Reducing the stress in our lives is not only possible; it is relatively simple to do. Here are some stress reduction and relaxation techniques that you can add to your daily life today!

Relaxation Technique #1: Vagus Nerve Exercises

The vagus nerve is part of the parasympathetic autonomic nervous system – the branch that dominates only when we’re relaxed. This branch is nicknamed the “rest and digest” branch because digestive processes can only function under a relaxed, parasympathetic state.

Your vagus nerve is connected to every organ in your torso except the adrenal glands, which pump out the stress hormones when you are stressed.

The vagus nerve has many impacts on digestive health, and stimulating this nerve is important for improving resilience in the face of stress. So how do we stimulate this nerve to make it function better?

The vagus nerve runs through the muscles in the back of your throat. Vibrations on these muscles can activate the nerve, which over time can help you bounce back from stress more easily.

Here are a couple simple things you can do to stimulate the nerve and improve your vagal tone:

  1. Gargle warm salt water (until your eyes start watering!)
  2. Sing at the top of your lungs! Or hum loudly.
  3. Use cold water for 1 minute at the end of your showers
woman gargling water in her bathroom

Luckily, practicing vagus nerve stimulation at home can be so simple! Both of these techniques are easy to do and can be added to your daily regimen immediately, so why not try them out today?

Relaxation Technique #2: Practice Mindfulness

Mindfulness involves simply being present in the moment and paying attention to any bodily sensations. We are predisposed to have our minds wander since we are constantly stimulated in our daily lives. Mindfulness techniques center you to notice your current physical and mental state without judgment. The continued practice of bringing attention to the present moment and how you are connecting with your surroundings is clinically shown to reduce stress and negative mental states.

woman meditating at her desk in front of her laptop

A common mindfulness method is to complete a body scan. To do this, you can be lying down, sitting, or standing. Just close your eyes, breathe slowly, and focus on how your body feels starting from your feet upward, or from your head downward. Focus on how your clothes feel on your body, how certain body parts feel touching each other, and any pressure felt from the ground or the chair. Doing this even just a couple times can help reduce stress and induce a feeling of peace.

Relaxation Technique #3: Yoga Nidra

Yoga nidra, also known as “Yogic Sleep,” is a form of pre-bedtime guided meditation that puts you in a very relaxed state. For most people, this form of meditation is much easier to accomplish than sitting still and trying to “clear your mind.” Practicing yoga nidra over time can lead to benefits such as better sleep, reduced stress, and improved wellbeing.

Yoga nidra involves lying down on a yoga mat (or even your mattress), setting a sankalpa (intention), and simply following what the guided meditation says. Some practices are 5 minutes, others can be an hour or longer. There are many audio guides of varying lengths available online that can easily be followed at home, so this practice is accessible to everyone!

woman laying on the floor yoga nidra

Yoga nidra is an easy way to reduce stress, relieve tension and pain, and connect with yourself on a deeper level. Practicing yoga nidra right before you go to sleep can clear the mind and allow yourself to tap into your subconscious self to reach your goals and intentions.

Relaxation Technique #4: Deep Breathing Exercises

One of the best relaxation techniques involves something that we usually do without any thought. Breathing is essential to human life, and is key in both the mindfulness and in yoga nidra practices mentioned above.

The diaphragm is the key muscle that is used in relaxed breathing states. However, many people breathe using their accessory respiratory muscles rather than the diaphragm.

To test whether you’re prone to dysfunctional breathing, place one hand on your chest and the other on your belly. Take a few deep breaths in, and pay attention to which hand is moving. Your belly should be the area that expands when you inhale. If your chest is expanding more than your belly, this is a sign that you might be in a sympathetic state, under stress.

Slow, deep breathing using your diaphragm improves efficiency within the lungs.  Clinical studies also show that deep breathing plays a huge role in our cardiovascular health and helps to decrease blood pressure. It can also promote higher heart rate variability (HRV), which is a sign of high vagal tone.

Studies suggest that practicing deep breathing exercises regularly for 3 months or longer can shift your autonomic nervous system to parasympathetic dominance – this means that deep breathing can modulate your stress response so that you are more resilient in the face of stress!

the words just breathe scratched into the sand on the beach at sunset

Deep breathing exercises have been practiced for centuries, especially in Eastern cultures. Western cultures are just now realizing the advantages of a more holistic approach to wellness, even though many practices have been around for hundreds of years. In yoga, breathing is called “pranayama.” One variation of pranayama is alternate nostril breathing.

How to do Alternate Nostril Breathing:

  • Sit in an upright, relaxed position and close your eyes. Place one hand with your palm facing upwards on top of your knee.
  • With your other hand, raise your pointer and middle fingers and lightly place them in between your eyebrows. Your ring and pinky fingers should cover one nostril, and your thumb covers the other nostril. Do not exert any hard pressure to your nose or forehead.
  • Exhale through your right nostril while holding the left nostril shut.
  • Inhale through your right nostril, then shut the right nostril and release the left nostril.
  • Exhale through the left nostril, while keeping the right nostril closed.
  • Inhale through the left nostril, then close the left nostril and exhale through the right nostril. This step completes one cycle of alternate nostril breathing.
  • Continue these steps for as long as needed to relax the mind.
  • Always inhale through the nostril you just exhaled through.
woman sitting outside in autumn practicing alternate nostril breathing

Another deep breathing exercise that can be used to calm your nerves is called 4×4 breathing (aka square/box breathing).

How to do 4×4 Breathing:

  • Sit or lie down in a comfortable, relaxed position and close your eyes. Release any tension from your body.
  • Inhale through your nose for 4 seconds
  • Hold your breath for 4 seconds.
  • Exhale through your mouth for 4 seconds.
  • Hold your breath for 4 seconds.
  • Repeat this cycle as many times as you want over the course of a few minutes until you feel a sense of calm.

 

Since stress negatively impacts our health, it is important for us to take back control in whatever ways we can. As you can see, none of these relaxation techniques are very difficult, so it is easy to get started today! Pick whichever relaxation technique works best for you, or combine multiple techniques and you may begin to feel less stressed within a short period of time.

woman singing into her shower head in the bathtub

Still feeling stressed over your gut health?

Schedule your free 15-minute strategy call today to help you get to the root cause of the problem, so you can start living your best life!

the top 4 types of relaxation techniques

 

 

 

Sources:

https://breathe.ersjournals.com/content/13/4/298

https://www.sciencedirect.com/science/article/abs/pii/S1566070201002673

https://search.proquest.com/openview/9b98ccfa3b77e8dc6667b20e1ca0f96c/1?pq-origsite=gscholar&cbl=37533

https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-rate-variability

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134749/

11Nov

Stress and the Digestive System

Stress is something that, unfortunately, we are all very familiar with. The gut problems that result from stress are also no stranger to most of us.

This blog will explain some of the physiological changes that happen in the body when we’re stressed out that lead to the discomfort you may be feeling.

Can stress cause gastrointestinal problems?

Think of any gut issue, and it’s extremely likely that it is somehow connected to stress. Many of us have experienced an upset stomach from stress at some point in our lives. There are many gastrointestinal (GI) symptoms that illustrate the connection between stress and the digestive system.

Here are some examples of GI symptoms that are related to stress:

  • Abdominal pain
  • Indigestion
  • Heartburn and acid reflux
  • Diarrhea
  • Constipation
  • Nausea and vomiting
woman holding stomach in pain

To some extent, all of us are familiar with most, if not all, of these uncomfortable symptoms.  Here, we will explain why these symptoms occur to explain the connection between stress and the digestive system.

Low Stomach Acid

Contrary to popular belief, the stomach actually produces less stomach acid (concentrated hydrochloric acid – HCl) when we’re under stress. So how does less acid lead to acid reflux and heartburn?

This happens because the sphincter muscle connection between the esophagus and the stomach relies on sufficient stomach acid production to determine when it should be closed. This means, when stomach acid levels are low, the opening stays open and what little acid there is in the stomach can now enter the esophagus and cause heartburn.

woman in black and white with cartoon stomach on fire

Low levels of stomach acid also cause issues with digestion. Certain nutrients may not be as easily absorbed because they won’t get properly broken down without enough stomach acid.

Also, any bacteria we consume with our food (or even bacteria that naturally live in the mouth) may not be killed, which could lead to food poisoning. This can also lead to other dysbiosis (microbial imbalance) issues in the gut, such as SIBO (small intestinal bacterial overgrowth).

Interrupted Bile Flow

Another symptom that is common with stress and the digestive system is interrupted bile flow. Bile is produced by the liver and stored in the gallbladder. When we’re stressed, bile flow is interrupted and grinds to a halt.

Why does this happen? First of all, the stress response suppresses bile release from the liver into the gallbladder because energy is being diverted away from digestive processes and towards your muscles. Also – since digestion stops when you’re stressed, the stomach doesn’t release any food into the small intestine, which is the signal for the gallbladder to pump bile to aid in digestion.

So why is this a problem? The gallbladder is the storage organ for bile, which assists with fat digestion. When the gallbladder is repeatedly inhibited from releasing its bile stores, the entire biliary system gets disrupted. 

Some issues that can arise include fat malabsorption, fat-soluble vitamin malabsorption, diarrhea, abdominal pain after eating fatty foods, nausea, and feeling heavy after eating. Interrupted bile flow can also cause bile to become over-concentrated with cholesterol and potentially lead to painful gallstones.

gallstones inside gallbladder

Changes to Gut Motility

Gut motility alteration also signals to the connection between stress and the digestive system.

The hormones that are released while you’re stressed out are shown to impact gut motility. This causes the upper gut (your stomach and small intestine) to slow down its digestion process and also decreases the absorption of nutrients. Food stays stagnant in the stomach and small intestine. Stagnant food causes issues such as malnutrition, abdominal distention, bloating, nausea, and vomiting. This is why you can sometimes feel nauseated or even vomit when you’re extremely nervous.

woman holding up cardboard image of intestines

The opposite situation usually happens in the large intestine. During stress, the large intestine speeds up, disregarding its duties of packing our excrement into shape and reabsorbing water. This reduced gut transit time explains why we might experience diarrhea when we’re stressed out.

Heightened Gut Hypersensitivity

Studies also show that sensitivity within the gut increases when we’re under stress. Heartburn and other gastrointestinal (GI) symptoms can actually feel worse when we’re under stress than the same symptoms feel when we’re relaxed.

This relates to irritable bowel syndrome (IBS) – where you experience hypersensitivity in addition to changes in motor function of the gut. Unfortunately, patients with IBS and other GI issues are subject to a vicious cycle where stress contributes to the severity of their symptoms, which then causes even more stress…

Weakened Immune System

Chronic stress can weaken the immune system, making it more likely that we will get sick. When we’re stressed out long-term, the continuous surges of cortisol and other hormones cause widespread inflammation and slow immune cell production, both of which can increase the risk of infection and tissue damage.

sick woman in blanket blowing nose looking at thermometer

Did you know that 60 to 70% of your immune system is in your gut? This makes sense when you really think about it. Our digestive systems are connected to the outside world – humans are essentially just tubes with a lot of complicated accessories.

People consume dangerous pathogens through food and drink every day. Our immune system needs to be especially active in our gut to help protect us from things like food poisoning and small intestine bacterial overgrowth (SIBO).

Hidden Inflammation

Inflammation is valuable in small doses. The inflammatory response is the part of the immune response that promotes tissue healing. Inflammation is supposed to stop once healing is complete, however, this doesn’t always happen. Chronic stress can lead to chronic inflammation, which can then contribute to much larger problems.

woman holding stomach with xray intestines

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are exactly what they sound like – diseases caused by excessive inflammation and irritation in the intestines. These are autoimmune conditions, where your immune system thinks your own cells are foreign enemies. Studies suggest that these diseases are ultimately triggered by disruptions in the immune function within the gut, imbalances in gut microbiota, and leaky gut – all of which can be the result of chronic stress.

A Quick Note About the Gut Microbiome

The bacteria that live in our digestive systems (mostly within the large intestine) are usually beneficial for us. They can produce various products such as essential vitamins and short chain fatty acids that our bodies need. 

Each person’s microbiome is as unique as his or her fingerprint. We obtain these bacteria throughout our lives, starting with our journey through the birth canal and continuing with exposure to the environments and foods we are raised with. These bacteria are there to work with the immune system to strengthen the gut lining, prevent inflammation, and protect against any intruding bacteria from colonizing where they don’t belong.

intestines with blue bacteria

Bacterial Imbalance of the Gut Microbiome

When we experience stress, the gut microbiome is altered. One way this can happen is because when digestion shuts down, any food in the small intestine just hangs out there. This means that our housekeeping system, the migrating motor complex, cannot sweep the small intestine clean of invading bacteria.

Without this housekeeper, any pathogenic or unwanted bacteria that has found its way into our intestines, through our food or from our mouths, is now likely to take refuge there. This can lead to an imbalanced microbiome, uncomfortable GI symptoms, increased colon inflammation, autoimmune diseases like Crohn’s disease, and conditions like SIBO.

microscopic bacteria in intestines

Something that you may find really interesting is that your personal microbiome also affects how you respond to stress. Research indicates that people who are able to stay calm during stressful situations have similar microbiomes, which are very different when compared to those who react the most strongly under stress.

The gut-brain connection is bidirectional, but the signals from the gut to the brain are much stronger than the other direction. We know that chronic stress can change both the proportions and the diversity of these bacteria in your gut. So when stress causes an imbalance in your gut bacteria, the newly reigning gut bacteria may actually diminish your resilience to stress.

It all boils down to the gut-brain connection!

When we’re stressed, the nerve that controls digestive functions doesn’t work properly. This contributes to the issues we spoke about above, like low stomach acid, low bile flow, issues with gut motility, inflammation, and more.

This extremely important nerve is called the vagus nerve, and it has become the subject of a lot of research in more recent years. It also has a vast impact on our mental health! The proper function of gut-brain connection via the vagus nerve is essential to maintaining our health and overall wellbeing.

brain neurons and nerves

You can get started on some relaxation techniques today in order to improve your vagus nerve function and reduce stress, so that you can achieve optimum gut health and function!

For guided assistance to get to the root cause of your gut problems, schedule your free 15-min appointment today!

I can order your comprehensive stool analysis so we can look for any maldigestion markers, inflammation, dysbiosis, metabolic imbalance, or infection that could be occurring within your gut!

 

 

 

 

Sources: 

http://www.med.unc.edu/ibs/files/2017/10/Stress-and-the-Gut.pdf

https://gut.bmj.com/content/47/6/861

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859128/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858318/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140465/

https://www.sciencedirect.com/science/article/pii/S2352289516300509

https://medicalxpress.com/news/2018-03-gut-bacteria-essential-healthy-immune.html#:~:text=The%20gut%20is%20able%20to,may%20impact%20how%20we%20behave.

25Oct

Adrenal Fatigue Recovery – Your Quick Guide to Adrenal Fatigue

Have you been extra stressed out recently due to the pandemic? Do you feel that your stress levels have negatively impacted your life and have contributed to you feeling burned out? You’re not alone! You may be dealing with something commonly referred to as Adrenal Fatigue. This blog will outline what exactly adrenal fatigue is, and give you some support for adrenal fatigue recovery.

Like many people nowadays you might be facing financial insecurities, unsure how to handle childcare or homeschooling, worrying about online classes, or just generally worrying about the future. All of these things are considered stressors.

stressed out woman with head in her hands at a desk with a laptop, phone, and 2 journals

Life sometimes hits us in a way that creates a cycle of constant stress. Many people have been under an unprecedented amount of stress due to the pandemic. And you are probably aware of how badly stress can make your body feel!

The human body has a hardwired response to stress, which enables us to focus and activate a response in the face of danger. However, the stress we face most days isn’t a matter of life or death… We can have emotional, perceived stress, physical stress from injuries, or chemical stress from smoke or pollutants. The human body reacts the same way to these types of stressors as it does to life-threatening situations.

When stress becomes chronic, the body’s adaptive response to danger becomes dysfunctional and ends up hurting our health in the long run. One of the results of this chronic stress is something called adrenal dysfunction often referred to as adrenal fatigue.

What is adrenal fatigue?

Adrenal fatigue is the end result of the constant cycle of stress. When people say adrenal fatigue, they probably mean adrenal dysfunction or HPA axis dysfunction. If left untreated, adrenal fatigue is often the end result of chronic adrenal dysfunction caused by chronic stress. 

The adrenal glands produce multiple hormones, most notably cortisol and epinephrine (aka adrenaline). These hormones are the ones that help us react to stressful situations. When the brain registers a stressor, a specific cascade of hormones are produced, eventually resulting in the release of adrenaline and cortisol from the adrenal glands. 

However, if the brain is constantly triggering the stress response, eventually the adrenal glands will not be able to keep up with the demands to produce these stress hormones. This is where adrenal fatigue sets in, and your entire body faces the consequences. This can happen quickly, or over the span of decades – it is all dependent on the individual!

Why should I care about cortisol for adrenal fatigue recovery?

Cortisol is a catabolic hormone, meaning that it helps to break things down within the body. This probably doesn’t really sound very good to you, and you would be correct – in chronically high levels, cortisol can do some serious damage. 

Excess cortisol:

  • Suppresses immune function 
  • Breaks down the gut mucosal barrier
  • Increases insulin resistance
  • Fat gain, especially around the abdomen
  • Inhibits the production of testosterone, estrogen, progesterone, DHEA, and more
  • Increases sodium retention and causes high blood pressure
  • Reduces levels of magnesium and zinc in the body
  • Alters thyroid function
  • Stimulates bone loss, contributing to osteoporosis

In addition, the downstream consequences of adrenal dysfunction can lead to the erosion or break down of the gut lining, which contributes to poor gut functioning.

Another problem that occurs is that when cortisol is being produced in excess, a very important hormone called DHEA (dehydroepiandrosterone gets produced in lower amounts than usual. Cortisol and DHEA have the same precursor hormone, called pregnenolone. When the demand to produce cortisol is consistently high over a long period of time, one of the results is that there is much less DHEA production.

What is DHEA?

DHEA is essentially the opposite of cortisol – it is an anabolic hormone, which does jobs that involve building materials and structures within the body.

Some benefits of DHEA include:

  • Opposes the negative effects of cortisol on the immune system
  • Improves muscle mass and decreases body fat
  • Precursor to testosterone
  • Supports recovery from stress
  • Lowers total blood cholesterol and LDL cholesterol
  • Involved in conversion of thyroid hormone to the active form
  • Stimulates building bones to prevent osteoporosis

You should notice that DHEA generally opposes the effects of cortisol.

So, in addition to all of the negative effects cortisol is having on your body, excess cortisol also reduces the positive effects of DHEA by limiting its production.

The relative amounts of these two hormones are important in determining which stage of adrenal fatigue you are in. Knowing which stage you are in helps your functional medicine dietitian determine what kind of treatment is required to get you back to optimal health. In other words, knowing which stage you are in sets the stage for adrenal fatigue recovery.

cortisol vs DHEA

There are 3 stages of HPA Axis Dysfunction / Adrenal dysfunction

A skilled practitioner is able to determine which stage of adrenal dysfunction you are in by looking at your adrenal hormone test results.

  • In stage 1 of adrenal dysfunction, your body is in a permanent alarm phase and is producing extremely high levels of cortisol, and DHEA levels are dropping.
  • During stage 2 of adrenal dysfunction, cortisol levels may seem normal, but DHEA levels are low. 
  • In stage 3, the body is producing very low amounts of cortisol and DHEA. This is the result of the system crashing completely. If this stage is reached, you will need more than just a lifestyle overhaul to address the issue. This is the stage that we consider true adrenal burn-out. 
3 stages of adrenal dysfunction

Possible signs and symptoms of chronic stress, HPA axis dysfunction, and adrenal burn-out:

  • Fatigue
  • Feeling tired but also wired
  • Sugar and simple carbohydrate cravings
  • Insomnia
  • Increased belly fat
  • Low energy and poor recovery from exercise
  • Poor immune function
  • Anxiety
  • Memory problems
  • Depression
  • Nutrient deficiencies
signs of adrenal burnout

Chronic conditions that can be affected by a hyperactive stress response:

  • Diabetes
  • High blood pressure (hypertension)
  • Cardiovascular Disease
  • Autoimmune illnesses
  • Chronic fatigue syndrome
  • Osteoporosis
  • Infertility
  • Digestive conditions (SIBO, IBS, IBD, etc.)

How to know if you are suffering from adrenal dysfunction 

If you are dealing with any of the symptoms or conditions listed above, you might be suspecting that you are in one of the stages of adrenal dysfunction. The only way to truly determine if this is true is to have your adrenal hormone levels tested with a saliva test. Salivary cortisol is used because it is the most convenient way to measure cortisol.

These adrenal hormone tests are noninvasive and easy to do in the comfort of your own home. Saliva testing involves spitting into a tube at specific intervals throughout the day. These saliva samples are then graphed and compared to the range of normal cortisol levels.

saliva test kit

The adrenals produce cortisol in what is called the circadian rhythm. This means that naturally, cortisol is produced throughout the day in a typical, distinct pattern.

Comparing your cortisol values to the standard circadian rhythm allows your functional medicine dietitian to determine whether or not you’re in adrenal dysfunction, and if so, which stage you are in. This information is usually enough for your practitioner to give you a treatment protocol that will help you get back into the normal range. Sometimes, other testing may be required in your personal adrenal fatigue recovery journey.

Graphic showing the cortisol circadian rhythm graph

So how exactly do we begin our journey to adrenal fatigue recovery?

Healing Adrenal Fatigue

The first step to improving your adrenal function is to test your adrenal hormone levels to be sure that you have adrenal dysfunction or insufficiency in the first place, and if you do have it, knowing which stage you are in. Depending on which stage you are in, there are different protocols.

Improve your stress resilience…

Remember that the stress response actually starts in the brain. How you perceive an event is actually more important than the event itself. This is why two different people who experience the same event may have drastically different emotional and psychological responses.

One person may get a parking ticket and think “UGH… this always happens to me! Why am I so unlucky?” and then they ruminate over the ticket all day. The other person who got a parking ticket may brush it off, consider it not a big deal, and not even think about it again. These two people experienced the same event, but only one of them triggered their stress response – and that person triggered it continuously throughout the day!

So, the first thing you can do to improve adrenal function is to dedicate some time to cultivating a more positive mindset and to make an effort to learn how to remain calm in the face of a potential stressor. Reminding yourself of things you are grateful for can help you in working towards a less reactionary approach to stress.

There are many relaxation techniques that you can practice that will help you gain more resilience in the face of stress. These relaxation techniques include: breathing exercises, mindfulness, meditation, vagus nerve activation, yoga, and much more. Find what method works for you, and remember that improving your stress resilience takes time!

Clean up your diet!

Adjusting your diet is also usually necessary. Reducing the amount of added sugars and highly processed foods in your diet is a good first step towards reducing hidden inflammatory stress within the body. Be sure to stay hydrated and to fuel your body with plenty of fiber, lots of fruits and vegetables, and sufficient amounts of protein and fat.

Variety is the key in any diet to ensure you consume adequate amounts of all the necessary vitamins and minerals. Don’t take any supplements without the approval and recommendation from your dietitian. These recommendations should be based on your lab results, because toxicity is always possible, which can do even more damage to your already stressed out body.

Get plenty of sleep!

Since cortisol is linked to our sleep-wake cycles, quality sleep is key to improving health outcomes. Blue light glasses are useful while looking at screens throughout the day and in the hours before bedtime to block the blue light emitted from the screens of our electronics.

Blue light exposure close to bedtime tricks the brain into thinking daylight is still present, and alters the circadian rhythm. Of course, it is much better to avoid this blue light exposure right before you sleep. Getting at least 7 hours of uninterrupted sleep in a dark, cool room is essential for high sleep quality.

Get to the root cause of digestive issues

If you’re experiencing gastrointestinal distress, it is possible that additional functional medicine testing is needed to determine the next steps. Any symptoms you have may be connected to the HPA axis dysfunction, so communicating with your functional medicine dietitian is extremely important. Chronic stress is linked to digestive issues such as microbiome imbalances (dysbiosis), small intestine bacterial overgrowth (SIBO), constipation, diarrhea, and much more. 

healing adrenal fatigue

When one system in the body goes awry, many others may follow. Catching adrenal dysfunction before it gets to stage 3 is ideal. However, there are treatment options if you do find yourself in stage 3.

Following the guidance your functional medicine dietitian sets out for you can improve so much more than just the adrenal fatigue alone.

Improving your quality of life starts with simply knowing where to begin!

 

Have you been feeling burned out? Do you want to get to the bottom of what is causing your symptoms? Schedule your appointment today to get started on your journey to adrenal fatigue recovery!

Complete the app-based 28-Day Adrenal Support Cleanse diet protocol for an adrenal reboot. 

Sign up for a free 15-minute nutrition strategy call for individualized support for your adrenal fatigue recovery!

21Oct

Cortisol Circadian Rhythm and its Impact on Health

Before electricity, our ancestors woke with the sun and slept with the moon. Humans have evolved to exist in 24 hour sleep-wake cycles, or circadian rhythms, that operate as part of our biology.

Circadian rhythms can be disrupted by the modern conveniences of technology, and these disruptions have real impacts on our health.

What are Circadian Rhythms?

Your circadian rhythm is essentially a master clock along with a set of other internal clocks that regulate various bodily processes. Circadian rhythms run on a 24 hour cycle, can be trained, and can be affected by temperatures.

This master clock is called the suprachiasmatic nucleus, which is located above the optic nerves that send signals from the eyes to the brain. The master clock directly responds to light, and is the reason why we have sleep-wake cycles that are determined by light exposure.

Light exposure (or lack there-of) can impact these sleep-wake cycles, especially in modern society with light switches and high levels of screen time.

How does the Cortisol Circadian Rhythm work?

The hypothalamic-pituitary-adrenal (HPA) axis, which is in control of your stress response, also follows a circadian rhythm for its release of cortisol from the adrenal glands.

Cortisol levels typically peak when we awaken (6 to 8 am). Then cortisol levels decrease throughout the day, staying low from around 6 pm until we fall asleep, when cortisol release starts to rise again. Check out the cortisol circadian rhythm graph below!

Cortisol’s circadian rhythm is essential for our health, playing a role in various processes that impact metabolism, repair cells, and strengthen our immune system. Disruptions in your HPA axis circadian rhythm can increase the risk of developing chronic conditions like obesity, heart disease, cancer, and diabetes.

There are many symptoms listed below that can be present when you are experiencing HPA axis dysfunction that precede these chronic conditions, which can definitely be addressed before the chronic conditions have a chance to develop.

Being exposed to threats throughout the day, whether real or perceived, causes spikes in cortisol that disrupt this important, natural rhythm. If stress is a normal part of your daily life, then this has an even greater impact on your cortisol circadian rhythm and may mean that you need extra support to reestablish a healthy hormone balance.

Signs you need a Circadian Rhythm Reset:

  • Fatigue
  • Body aches, especially in the neck and back
  • Poor memory and feeling “foggy headed”
  • Poor immunity, or getting sick frequently
  • Gastrointestinal dysfunction
  • Weight gain, especially around the abdomen
  • Hair loss
  • Skin issues like acne, dryness, and dullness
  • Reduced sex drive
  • Depression or anxiety
  • Sleep disruptions, like insomnia or trouble staying asleep

So how do I know if my circadian rhythm has been disrupted? There is a test for that! 

How to Check Cortisol Levels 

One of the most accurate ways to determine whether you’re experiencing some HPA axis circadian rhythm disruptions is to get your cortisol levels tested with a practitioner-ordered home cortisol test.

Your functional medicine practitioner will order your adrenal stress hormone test, and after the results come back you will be able to get a better idea of how your cortisol circadian rhythm is functioning (or malfunctioning). Depending on where you fall within the cortisol normal range, you may find out that you are on the path to adrenal burn out.

This test is an easy and effective means for determining whether your stress response is hyperactivated. Cortisol patterns are considered markers of wellness and can be used to draw a roadmap to recovery. Knowing the effects that stress is having on your stress hormones is the first step from which a personalized protocol can be developed.

How to Reset Circadian Rhythm – Getting Back into Rhythm

Once you get started on the road towards recovering your circadian rhythm, there are many lifestyle factors that can be adjusted in order to achieve maximal results. Getting started by adding some relaxation techniques into your daily life will help set the stage for healthier responses to stressors, whenever they occur.

Woman with arms stretched up at sunrise

If you’re one of those people who is getting less than 6 hours of sleep per night, one of the simplest things you can do to better your health is to improve the duration of sleep to a minimum of 7 hours per night, along with synchronizing your sleep-wake cycles to your natural circadian rhythm.

Humans need to sleep to survive, and we need enough sleep to be healthy. No matter how much we need to accomplish in our daily lives, the fact remains that sleep is essential at the end of the day, and most people should be trying to get more of it.

Sleep isn’t always a simple thing for people, even if we know how important it is.

In fact, if you are under high amounts of stress (and thus consistently have constant spikes in cortisol), it is likely that sleep is quite difficult for you. So, addressing your cortisol circadian rhythm imbalances is actually one of the best things you can do in order to improve your sleep, improve your health, and improve your life.

So how can you get more sleep? There are many ways to improve your sleep hygiene in order to prime yourself for better and longer sleep. You can learn about these methods, along with many other lifestyle hacks, when you sign up for my Adrenal Reboot Program!

Joining my Adrenal Reboot Program will help get you started on a personalized track towards improving your HPA axis function, your cortisol circadian rhythm, and improving your overall health!

Schedule your free 15 minute Discovery Call today!